Umphandi waseFransi uphakamise ulwazi ngeengozi zeenaliti ezibukhali kwiilabhoratri emva kwengozi embi ebandakanya ukuvuza kwesinyibilikisi rhoqo. Ngoku ucela ukuphuhliswa kwezinto zokutshintsha iinaliti zokudlulisa izinyibilikisi okanye ii-reagents ukuphucula ukhuseleko lwelabhoratri. 1
NgoJuni 2018, umfundi oneminyaka engama-22 ubudala uNicolas wayesebenza kwilebhu kaSebastien Vidal kwiYunivesithi yaseLyon 1. Wagalela isirinji ye-dichloromethane (DXM) kwiflaski waza ngempazamo wahlaba umnwe wakhe. UVidal wabala ukuba malunga namaconsi amabini okanye ngaphantsi kwe-100 microliters ye-DXM asele kwinaliti waza wangena emnweni.
Uthotho lweefoto ezinemifanekiso lubonisa okwenzekileyo emva koko – inqaku lemagazini lilumkisa ukuba abanye banokufumana imifanekiso (engezantsi) iphazamisa. Malunga nemizuzu eli-15 emva kokuhlatywa ngenaliti, uNicolas wavela ibala elimfusa emnweni wakhe. Emva kweeyure ezimbini, imiphetho yeeplaque ezimfusa yaqala ukuba mnyama, nto leyo ebonisa ukuqala kwe-necrosis – ukufa kweeseli. Ngeli xesha, uNicholas wakhalaza ngokuba iminwe yakhe yayishushu kwaye wayengenakukwazi ukuyishukumisa.
UNicholas kwafuneka atyandwe ngokukhawuleza ukuze asindise umnwe wakhe. Oogqirha botyando, ababecinga ukuba kuza kufuneka anqunyulwe, bakwazile ukususa ulusu olufileyo olujikeleze inxeba lokuhlatywa baza balwakha kwakhona ulusu besebenzisa i-skin graft esandleni sikaNicholas. Kamva lo gqirha wotyando wakhumbula ukuba kwiminyaka yakhe engama-25 esebenza kumagumbi ongxamiseko, wayengazange abone ukwenzakala okunjalo.
Iminwe kaNicholas ngoku sele ibuyele esiqhelweni, nangona ukudlala kwakhe isiginci kwakunesifo esibangela ukuba imithambo-luvo yakhe yonakale, nto leyo eyamenza wabuthathaka amandla akhe kunye nobuchule bakhe.
I-DCM yenye yezona zinyibilikisi zendalo ezisetyenziswa kakhulu kwiilebhu zekhemistri yokwenziwa. Ulwazi lokulimala kwe-DCM kunye nephepha layo ledatha yokhuseleko lwezinto (MSDS) zibonelela ngeenkcukacha malunga nokudibana kwamehlo, ukudibana nolusu, ukuginywa kunye nokuphefumla, kodwa kungekhona xa kujojowe, uVidal waphawula. Ngexesha lophando, uVidal wafumanisa ukuba isiganeko esifanayo senzeke eThailand, nangona le ndoda yazijova ngokuzithandela ngeemililitha ezi-2 ze-dichloromethane, iziphumo zayo zaxelwa kwisibhedlele saseBangkok. 2
Ezi meko zibonisa ukuba iifayile ze-MSDS kufuneka zitshintshwe ukuze zibandakanye ulwazi olunxulumene ne-parenterals, utshilo uVidal. “Kodwa igosa lam lokhuseleko eyunivesithi lindixelele ukuba ukuguqula iifayile ze-MSDS kuya kuthatha ixesha elide kwaye kufuna idatha eninzi ukuba iqokelelwe.” Ezi ziquka izifundo ezineenkcukacha zezilwanyana ukuze kuphinde kuvele ingozi, uhlalutyo lomonakalo wezicubu, kunye novavanyo lwezonyango.
Iminwe yabafundi kwizigaba ezahlukeneyo emva kokufakwa ngengozi kwe-methylene chloride encinci. Ukusuka ekhohlo ukuya ekunene, imizuzu eli-10-15 emva kokwenzakala, emva koko iiyure ezi-2, iiyure ezingama-24 (emva kotyando), iintsuku ezi-2, iintsuku ezi-5, kunye nonyaka omnye (zombini imifanekiso engezantsi)
Ngenxa yokunqongophala kolwazi malunga nokuphunyezwa kwe-DCM, uVidal unethemba lokuba eli bali liza kusasazwa ngokubanzi. Ingxelo iyakhayo. Uthe olu xwebhu [lusasazwe ngokubanzi]. “Amagosa okhuseleko avela kwiiyunivesithi zaseKhanada, e-US naseFransi andixelele ukuba aza kufaka eli bali kwiikharityhulam zabo. Abantu basibulele ngokwabelana ngeli bali. Abaninzi babengafuni ukuthetha ngalo ngenxa yokoyika ukubhengezwa kakubi [ngeziko labo] Kodwa amaziko ethu ebexhasa kakhulu kwasekuqaleni kwaye asaxhasa.
UVidal ukwafuna uluntu lwezenzululwazi kunye nababoneleli ngeekhemikhali ukuba baphuhlise iindlela ezikhuselekileyo kunye nezixhobo ezizezinye zeenkqubo zesiqhelo ezifana nokudluliselwa kweekhemikhali. Enye ingcinga kukusebenzisa inaliti "ethe tyaba" ukuthintela amanxeba okubhoboza. "Ziyafumaneka ngoku, kodwa sihlala sisebenzisa iinaliti ezithe tyaba kwikhemistri yendalo kuba kufuneka singenise izinyibilikisi ngokusebenzisa izithinteli zerabha ukukhusela imithambo yethu yokusabela emoyeni/ukufuma ngaphandle. Iinaliti "ezithe tyaba" azinakudlula kwizithinteli zerabha. Lo asingombuzo ulula, kodwa mhlawumbi olu kusilela luya kukhokelela kwiingcinga ezilungileyo.
U-Alain Martin, umphathi wezempilo nokhuseleko kwiSebe leKhemistri kwiYunivesithi yaseStrathclyde, uthe akakaze ayibone ingozi enjalo. “Kwilabhoratri, kusetyenziswa iisirinji ezineenaliti, kodwa ukuba ukuchaneka kubalulekile, ukusebenzisa ii-micropipettes kunokuba lolona khetho lukhuselekileyo,” wongeza, kuxhomekeke kuqeqesho, njengokukhetha amacebiso nokusebenzisa ii-pipettes ngokuchanekileyo. “Ngaba abafundi bethu bafundiswa indlela yokuphatha iinaliti ngokufanelekileyo, indlela yokufaka nokususa iinaliti?” wabuza. “Ngaba kukho umntu ocinga ukuba yintoni enye enokusetyenziswa? Mhlawumbi hayi.
2 K. Sanprasert, T. Thangrongchitr kunye noN. Krairojananan, eAsia. Pakisha. J. Med. I-Toxicology, 2018, 7, 84 (DOI: 10.22038/apjmt.2018.11981)
Iminikelo yezigidi ezingama-210 zeerandi evela kusomashishini weModerna kunye nomtyali-mali uTim Springer ukuxhasa uphando oluqhubekayo
Ukudibana kovavanyo lwe-X-ray diffraction kunye nokulinganisa kubonisa ukuba ukukhanya okukhulu kwelaser kunokuguqula i-polystyrene.
© Royal Society of Chemistry document.write(new Date().getFullYear()); Inombolo yobhaliso lweSisa: 207890