I-NICE icebise okokuqala unyango olutsha olunokunceda iintsana, abantwana kunye nabantu abancinci abafumana unyango lomhlaza ukuba bangaphulukani nokuva.
I-Cisplatin liyeza elinamandla le-chemotherapy elisetyenziswa kakhulu ukunyanga iintlobo ezininzi zomhlaza wabantwana. Ngokuhamba kwexesha, i-cisplatin inokuqokelelana endlebeni engaphakathi kwaye ibangele ukudumba kunye nomonakalo owaziwa ngokuba yi-ototoxicity, enye yezizathu zokulahlekelwa kukuva.
Iingcebiso zokugqibela ezicetyisiweyo zicebisa ukusetyenziswa kwe-anhydrous sodium thiosulfate, ekwaziwa ngokuba yiPedmarqsi kwaye yenziwe yiNorgine, ukuthintela ukulahleka kokuva okubangelwa yi-cisplatin chemotherapy kubantwana abaneminyaka ephakathi kwenyanga ukuya kwi-17 ubudala abaneethumba eziqinileyo ezingasasazekanga kwezinye iindawo zomzimba.
Malunga nama-60% abantwana abanyangwa nge-cisplatin baya kuba nokulahlekelwa kukuva okungapheliyo, kwaye kufunyenwe amatyala amatsha angama-283 okulahlekelwa kukuva okubangelwa yi-ototoxic kubantwana abangaphantsi kweminyaka eli-18 ubudala eNgilani phakathi kowama-2022 nowama-2023.
Eli yeza, elinikwa njengonyango ngumongikazi okanye ugqirha, lisebenza ngokubophelela kwi-cisplatin engakhange ithathwe ziiseli kwaye ithintele ukusebenza kwayo, ngaloo ndlela ithintela umonakalo kwiiseli zendlebe. Ukusetyenziswa kwe-sodium thiosulfate anhydrous akuchaphazeli ukusebenza kwe-cisplatin chemotherapy.
Kuqikelelwa ukuba kunyaka wokuqala wokucetyiswa kokusetyenziswa kwe-anhydrous sodium thiosulfate, malunga nezigidi ezingama-60 zabantwana kunye nolutsha eNgilane baya kufaneleka ukufumana eli yeza.
Ukulahlekelwa kukuva ngenxa yonyango lomhlaza kunokuba nefuthe elibi ebantwaneni nakwiintsapho zabo, ngoko ke siyavuya ukukwazi ukucebisa olu khetho lonyango lutsha.
Eli liyeza lokuqala eliye langqinwa ukuba lithintela kwaye linciphisa iziphumo zokulahlekelwa kukuva kwaye liza kuba nefuthe elikhulu kubomi babantwana nabantu abancinci.
UHelen uqhube wathi: “Ingcebiso yethu yolu nyango lutsha ibonisa ukuzinikela kwe-NICE ekugxileni kwizinto ezibaluleke kakhulu: ukubonelela ngonyango olungcono kwizigulana ngokukhawuleza nokuqinisekisa ixabiso elifanelekileyo lemali kumhlawuli werhafu.”
Idatha evela kuvavanyo lwezonyango ezimbini ibonise ukuba unyango luphantse lwanciphisa isiqingatha izinga lokulahlekelwa kukuva kubantwana abafumene i-cisplatin chemotherapy. Olunye uvavanyo lwezonyango lufumanise ukuba abantwana abafumene i-cisplatin chemotherapy elandelwa yi-anhydrous sodium thiosulfate babenezinga lokulahlekelwa kukuva eliyi-32.7%, xa kuthelekiswa nezinga lama-63% lokulahlekelwa kukuva kubantwana abafumene i-cisplatin chemotherapy yodwa.
Kolunye uphando, ama-56.4% abantwana abafumana i-cisplatin yodwa baye balahlekelwa kukuva, xa kuthelekiswa nama-28.6% abantwana abafumana i-cisplatin elandelwa yi-anhydrous sodium thiosulfate.
Ezi mvavanyo zikwabonise ukuba ukuba abantwana baye balahlekelwa kukuva, ngokubanzi bekungekho nzima kangako kwabo basebenzisa i-anhydrous sodium thiosulfate.
Abazali baxelele ikomiti ezimeleyo ye-NICE ukuba ukuba ukulahlekelwa kukuva kwenzeka ngenxa ye-cisplatin chemotherapy, oku kunokuchaphazela uphuhliso lwentetho nolwimi, kunye nokusebenza esikolweni nasekhaya.
Siyavuya ukwazisa ukuba eli yeza litsha liza kusetyenziswa kwizigulane eziselula ezinyangwa ngumhlaza ukuthintela ukulahlekelwa kukuva njengesiphumo esibi se-cisplatin chemotherapy.
URalph uqhube wathi: “Silangazelela ukubona eli yeza kwizibhedlele kulo lonke ilizwe kwaye sinethemba lokuba bonke abantwana abanokuzuza kulo baza kufikelela kolu nyango lusindisa ubomi kungekudala. Siyabulela kubaxhasi bethu ngegalelo labo, eliye lenza i-RNID yakwazi ukunika i-NICE izimvo ezibalulekileyo kunye nobungqina bokunceda ukuba eli yeza lifumaneke ngokubanzi kulo lonke elase-UK. Eli lixesha lokuqala ukuba iyeza lenziwe ngokukodwa ukuthintela ukulahleka kokuva kwaye licetyiswa ukuba lisetyenziswe kwi-NHS. Eli linyathelo elibalulekileyo eliya kunika abo batyala imali kwaye baphuhlise unyango lokulahleka kokuva ukuzithemba kokuba banokuzisa ichiza ngempumelelo kwimarike.”
Olu nyango luza kufumaneka kwi-NHS eNgilane kwiinyanga ezintathu emva kokupapashwa kwesikhokelo sokugqibela se-NICE.
Le nkampani ingene kwisivumelwano esiyimfihlo sorhwebo sokubonelela nge-anhydrous sodium thiosulfate kwiNkonzo yezeMpilo yeSizwe ngexabiso eliphantsi.